Christina Haston is an associate professor of medical physics at UBC’s Okanagan campus. - Credit: UBCO

UBC study could spare cancer patients from side effects of radiation

Her research has drawn a connection of Chromosome 6 genes to pulmonary fibrosis susceptibility.

A UBC Okanagan researcher has determined that genes on a specific chromosome may be the answer as to why thoracic radiotherapy leads to a lung injury in some lung cancer patients.

Christina Haston, an associate professor of medical physics, recently published a study examining how Chromosome 6 can contribute to radiation-induced pulmonary fibrosis. Her study finds that genetic differences can determine whether or not this lung injury follows radiotherapy in an experimental system, according to UBCO in a news release.

“Currently, 50 per cent of cancer patients in Canada receive radiation therapy as part of their treatment course,” she said. “In addition to effects on the tumour, up to 30 per cent of these patients develop side effects to this treatment, or injuries to non-tumour tissue.”

RELATED: UBC Okanagan study evaluates virtual educational care

Pulmonary fibrosis is a progressive disease related to damaged lung tissue, making it difficult for patients to breathe and process oxygen effectively. Some lung cancer patients have developed pulmonary fibrosis after radiation, while patients with other cancers have developed it after receiving a specific cancer medication called Bleomycin.

“One of the limiting side effects of thoracic radiotherapy is the development of pulmonary fibrosis in a susceptible subpopulation of treated patients,” said Haston. “However, the specific pathways contributing to fibrosis susceptibility in radiotherapy patients remain unidentified.”

It has been thought that white blood cells, the body’s natural defence mechanism, may contribute to pulmonary fibrosis. Building on this, her research has drawn a connection of Chromosome 6 genes to fibrosis susceptibility, the release said.

She examined the susceptibility to pulmonary fibrosis on lab mice after radiation therapy and on mice after treatment of Bleomycin. The mice with a replaced Chromosome 6 were protected from both radiation-induced and Bleomycin-induced pulmonary fibrosis.

RELATED: Globe trotting biology student to study at UBCO

“The recent findings by our lab have specifically identified these genetic differences to reside in Chromosome 6,” she added, explaining that her work may open the door to individualized cancer treatments, depending on a person’s specific genetic makeup.

Her study, published in Radiation Research, was supported by the Canadian Institutes of Health Research.

“This research aims to develop a pre-treatment marker based on knowledge of specific genes of radiation injury response,” she said. “Such a marker could significantly affect Canadians with cancer, by sparing side effects and increasing the dose to the tumour which may, in turn, increase cure rates.”


edit@kelownacapnews.com

Like us on Facebook and follow us on Twitter.

Just Posted

Disaster risk reduction course open to Campbell River high school students this fall

SRD protective services coordinator hopes program will eventually become integrated into curriculum

Large sections of Baikie Island Nature Reserve in Campbell River still in need of major attention

Greenways Land Trust has been looking for almost $1 million to address south side of conservancy

VIDEO: Break-in third this year at Indigenous art stores in Campbell River

Awatin Aboriginal Arts robbed for second time in 2019; Wei Wai Kum House of Treasures robbed in June

Artists ‘battle’ it out in Campbell River’s downtown

The excitement of Art Battle hit Campbell River’s streets Wednesday night as… Continue reading

Rich the Vegan scoots across Canada for the animals

Rich Adams is riding his push scooter across Canada to bring awareness to the dog meat trade in Asia

Ottawa fights planned class action against RCMP for bullying, intimidation

The current case is more general, applying to employees, including men, who worked for the RCMP

Alberta judge denies B.C.’s bid to block ‘Turn Off the Taps’ bill

He said the proper venue for the disagreement is Federal Court

Canadian high school science courses behind on climate change, says UBC study

Researchers found performance on key areas varies by province and territory

Six inducted into BC Hockey Hall of Fame

The 26th ceremony in Penticton welcomed powerful figures both from on and off the ice

RCMP investigate two shootings in the Lower Mainland

Incidents happened in Surrey, with a victim being treated at Langley Memorial Hospital

CRA program to help poor file taxes yields noticeable bump in people helped

Extra money allows volunteer-driven clinics to operate year-round

Recall: Certain Pacific oysters may pose threat of paralytic shellfish poisoning

Consumers urged to either return affected packages or throw them out

Most Read